1. Home
  2. Vol 9, No 2 (2023)
  3. Fardela

Analisis Dosis OAR Pada Radioterapi Kanker Payudara Sinistra Di Rumah Sakit Universitas Andalas

Ramacos Fardela, Adinda Mahesa Putri, Innes Andriani, Fiqi Diyona, Rika Analia, Dedi Mardiansyah

Abstract


Kanker payudara menempati urutan pertama di Indonesia dan menjadi salah satu penyumbang kematian utama akibat kanker. Penanganan Kanker payudara dapat dilakukan menggunakan terapi radiasi atau biasa disebut radioterapi. Salah satu modalitas yang sering digunakan dalam radioterapi adalah Linear Accelerator (Linac). Agar terapi radiasi dapat mengenai target kanker dan aman Organ-At-Risk (OAR) perlu dilakukan evaluasi perencanaan terapi radiasi. Evaluasi dilakukan terhadap dua teknik perencanaan terapi radiasi yaitu teknik Three Dimensional Conformal Radiotherapy (3D-CRT) dan Intensity Modulated Radiation Therapy (IMRT). Uji terapi radiasi dilakukan terhadap 3 orang pasien kanker payudara kiri. Hasil analisis dosis pada OAR menggunakan teknik 3D-CRT diperoleh sebaran dosis target dan perlindungan terhadap OAR lebih baik dibandingkan dengan teknik perencanaan 2D. Perencanaan terapi radiasi terbaik diperoleh pada teknik IMRT. Pada teknik perencanaan tersebut diperoleh sebaran dosis lebih homogen pada target maupun capaian dosis pada OAR sekitar target kanker.

Keywords


mammae; LINAC; PDD; 3D-CRT

References


American Cancer Society. (2022). Breast Cancer What is breast cancer? American Cancer Society. Cancer Facts and Figures Atlanta, Ga: American Cancer Society, 1-19. http://www.cancer.org/cancer/breast- cancer/about/what-is-breast-cancer.html.

Azizah, M., Milvita, D., Herlida, S. & Yudi Pati Sandy, K. (2016). Verifikasi Dosis Radiasi Kanker Menggunakan TLD-100 pada Pasien Kanker Payudara dengan Penyinaran Open System. Jurnal Fisika Unand, 5(2). https://doi.org/10.25077/jfu.5.2.147-152.2016

Bucht, H., Tuncay, E., Darendeliler, E. & Kemikler, G. (2018). Absolute dose verification of static intensity modulated radiation therapy (IMRT) with ion chambers of various volumes and TLD detectors. Reports of Practical Oncology and Radiotherapy, 23(4), 242–250. https://doi.org/10.1016/j.rpor.2018.04.001

Cho, B. (2018). Intensity-modulated radiation therapy: a review with a physics perspective. Radiation oncology journal, 36(1), 1. https://doi.org/10.3857/roj.2018.00122

Elvira, R., Taufiq, I., Adrial, R., & Ilyas, M. (2021). Analisis Perencanaan Radioterapi Pasien Kanker Nasofaring Menggunakan Teknik Intensity Modulated Radiotherapy. Jurnal Fisika Unand, 10(3), 337-343. https://doi.org/10.25077/jfu.10.3.337-343.2021

Febrietri, O., Milvita, D., & Diyona, F. (2020). Analisis Dosis Radiasi Paru-Paru Pasien Kanker Payudara dengan Teknik Three Dimensional Conformal Radiation Therapy (3D-CRT) Berdasarkan Grafik Dose Volume Histogram (DVH). Jurnal Fisika Unand, 9(1), 110-117. https://doi.org/10.25077/jfu.9.1.110-117.2020

Freire, L., Calado, A., Cardoso, J.V., Santos, L.M. & Alves, J.G. (2008). Comparison of LiF (TLD-100 and TLD-100H) Detectors for Extremity Monitoring, Radiation Measurements, Vol. 43, No. 2, Elsevier, hal. 646- 650. https://doi.org/10.1016/j.radmeas.2007.12.013

International Atomic Energy Agency. (2000). Absorbed Dose Determination in External Beam Radiotherapy, Technical Reports Series 398, IAEA, Vienna.

International Atomic Energy Agency. (2012). External Photon Beams Physical Aspeks, IAEA, Vienna.

Iqbal, M., Milvita, D., & Ilyas, M. (2023). Analisis Perencanaan Radioterapi Menggunakan Teknik Intensity Modulated Radiotherapy (IMRT) pada Pasien Kanker Serviks. Jurnal Fisika Unand, 12(1), 164-170. https://doi.org/10.25077/jfu.12.1.164-170.2023

Kemenkes Homepage. (2013). Panduan Penatalaksanaan Kanker Payudara, Kementrian Kesehatan, Komite Penanggulangan Kanker Nasional, http://kanker.kemenkes.go.id (Diakses Maret 2023).

Kemenkes Homepage. (2019). Hari kanker sedunia diperingati setiap tanggal 4 februari, https://www.kemkes.go.id/article/view/19020 100003/hari- kanker-sedunia-2019.html (Diakses Maret 2023).

Kementerian Kesehatan RI. (2022). Kanker Payudara Paling Banyak di Indonesia, Kemenkes Targetkan Pemerataan Layanan Kesehatan Sehat Negeriku. Biro Komunikasi Dan Pelayanan Masyarakat, 8–9. https://sehatnegeriku.kemkes.go.id/baca/umum/20220202/1639254/kanker-payudaya- paling-banyak-di-indonesia-kemenkes- targetkan-pemerataan-layanan-kesehatan/ (Diakses Maret 2023).

Khan, F.M. & Gibbons, J.P. (2014). The Physics of Radiation Therapy, The 5 th edition, Lippincott Williams & Wilkins, USA.

Koka, K., Verma, A., Dwarakanath, B. S., & Papineni, R. V. (2022). Technological advancements in external beam radiation therapy (EBRT): An indispensable tool for cancer treatment. Cancer Management and Research, 1421-1429. https://doi.org/10.2147/CMAR.S351744

Mayles, P. (2007). Handbook of Radiotherapy Physics: Teori and Practice, Taylor and Francis Group, New York.

Mayles, P. (2011). Development of Procedures For In Vivo Dosimetry in Radiotherapy. Radiotherapy and Oncology, 99, S225.

Montay‐Gruel, P., Corde, S., Laissue, J. A., & Bazalova‐Carter, M. (2022). FLASH radiotherapy with photon beams. Medical Physics, 49(3), 2055-2067. https://doi.org/10.1002/mp.15222

Podgorsak, E.B. (2005). Radiation Oncology Physics: A Handbook for Teachers and students, IAEA, Vienna.

Pramesti, W. S., Yuana, F., Herwiningsih, S., Hentihu, F. K., & Anto, A. K. (2023). Analisis sebaran dosis organ at risk (OAR) pada perencanaan radioterapi kanker payudara kiri dengan teknik 3D-CRT melalui dose volume histogram (DVH). Journal of Medical Physics and Biophysics, 10(1), 28-38.

Salimi M, Abi KST, Nedaie HA, Hassani H, Gharaati H, Samei M, Shahi R, Zarei H. Assessment and Comparison of Homogeneity and Conformity Indexes in Step-and-Shoot and Compensator-Based Intensity Modulated Radiation Therapy (IMRT) and Three-Dimensional Conformal Radiation Therapy (3D CRT) in Prostate Cancer. J Med Signals Sens. 2017 Apr-Jun;7(2):102-107. PMID: 28553583; PMCID: PMC5437761.

Susworo, R. & Kodrat H. (2017) Dasar Dasar Radioterapi Tata Laksana Radioterapi Penyakit Kanker, Edisi II, UI Press, Jakarta.

Susworo, R. (2007). Dasar-Dasar Radioterapi, UI Press, Jakarta.

Yang, H. J., Kim, T. H., Schaarschmidt, T., Park, D. W., Kang, S. H., Chung, H. T., & Suh, T. S. (2022). A multivariate approach to determine electron beam parameters for a Monte Carlo 6 MV Linac model: Statistical and machine learning methods. Physica Medica, 93, 38-45. https://doi.org/10.1016/j.ejmp.2021.12.005.


Full Text: PDF

DOI: 10.15548/nsc.v9i2.6785

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Natural Science

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.