Strategi Kontrol Optimal pada Model Dinamika Penyebaran Cacar Monyet (Monkeypox)

Dewi Suhika

Abstract


Monkeypox is an infectious disease that requires serious attention due to its rapid rate of spread. This study aims to analyze the dynamics of monkeypox transmission using the SEIR epidemiological model and to design an optimal control strategy to reduce the number of infections and control costs. The implemented control strategies include quarantine and health campaigns, which were designed using the Pontryagin maximum principle approach. Numerical simulations were conducted to compare scenarios without control and with optimal control. The results show that the optimal control strategy is effective in reducing the number of exposed and infected individuals. In the scenario without control, the total number of infections reached 26,481 individuals, whereas, with optimal control, infections were reduced to 267 individuals, demonstrating a reduction of 99.29%. Additionally, optimal control slowed the spread of the disease, allowing more time for additional interventions such as vaccination or treatment. This study concludes that optimal control strategies based on mathematical models are an effective and efficient approach to controlling the spread of monkeypox. This approach can serve as a valuable guide for developing policies to control infectious diseases in the future.


Keywords


monkeypox, optimal control, SEIR

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References


A. Sharma, H. Prasad, N. Kaeley, A. Bondalapati, L. Edara, and Y. A. Kumar, “Monkeypox epidemiology, clinical presentation, and transmission: a systematic review,” Dec. 01, 2023, BioMed Central Ltd. doi: 10.1186/s12245-023-00491-3.

O. Mitjà et al., “Monkeypox,” Jan. 07, 2023, Elsevier B.V. doi: 10.1016/S0140-6736(22)02075-X.

D. E. Martínez-Fernández et al., “Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies,” Jul. 01, 2023, Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390/pathogens12070947.

Y. H. Luo, T. Zhang, J. L. Cao, W. S. Hou, A. Q. Wang, and C. H. Jin, “Monkeypox: An outbreak of a rare viral disease,” Feb. 01, 2024, Elsevier Ltd. doi: 10.1016/j.jmii.2023.12.006.

J. Ferdous, M. A. Barek, M. S. Hossen, K. K. Bhowmik, and M. S. Islam, “A review on monkeypox virus outbreak: New challenge for world,” Health Sci Rep, vol. 6, no. 1, Jan. 2023, doi: 10.1002/hsr2.1007.

M. Sari and N. Hairunisa, “A REVIEW OF THE MONKEYPOX OUTBREAK IN INDONESIA IN 2022,” DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro), vol. 11, no. 5, pp. 268–274, Sep. 2022, doi: 10.14710/dmj.v11i5.35895.

E. Alakunle et al., “A comprehensive review of monkeypox virus and mpox characteristics,” 2024, Frontiers Media SA. doi: 10.3389/fcimb.2024.1360586.

M. Banuet-Martinez et al., “Monkeypox: A review of epidemiological modelling studies and how modelling has led to mechanistic insight,” May 23, 2023, Cambridge University Press. doi: 10.1017/S0950268823000791.

D. Suhika, “Efektivitas Skrining Genetik dalam Pengendalian Talasemia Beta Mayor di Indonesia Menggunakan Kontrol Backstepping,” Journal of Science and Technology, vol. 4, no. 2, pp. 108–118, 2024.

D. Suhika, R. Saragih, and D. Handayani, “Application of optimal control on mathematical model for spreading of Covid-19,” AIP Publishing., vol. 3083, Jul. 2024, doi: 10.1063/5.0225256.

C. E. Madubueze, S. Dachollom, and I. O. Onwubuya, “Controlling the Spread of COVID-19: Optimal Control Analysis,” Comput Math Methods Med, vol. 2020, 2020, doi: 10.1155/2020/6862516.

D. Bentaleb, Z. Khatar, and S. Amine, “Epidemiological modeling of monkeypox clades: a dual-strain SEIR approach with stability, bifurcation, and sensitivity analysis,” Model Earth Syst Environ, 2024, doi: 10.1007/s40808-024-02162-5.

O. J. Peter, C. E. Madubueze, M. M. Ojo, F. A. Oguntolu, and T. A. Ayoola, “Modeling and optimal control of monkeypox with cost-effective strategies,” Model Earth Syst Environ, vol. 9, no. 2, pp. 1989–2007, Jun. 2023, doi: 10.1007/s40808-022-01607-z.

O. J. Peter, F. A. Oguntolu, M. M. Ojo, A. Olayinka Oyeniyi, R. Jan, and I. Khan, “Fractional order mathematical model of monkeypox transmission dynamics,” Phys Scr, vol. 97, no. 8, Aug. 2022, doi: 10.1088/1402-4896/ac7ebc.

T. Li and Y. Guo, “Modeling and optimal control of mutated COVID-19 (Delta strain) with imperfect vaccination,” Chaos Solitons Fractals, vol. 156, Mar. 2022, doi: 10.1016/j.chaos.2022.111825.

D. Suhika, R. Saragih, D. Handayani, and M. Apri, “Optimal control strategies based on extended Kalman filter in mathematical models of COVID-19,” International Journal of Electrical and Computer Engineering, vol. 14, no. 6, pp. 6300–6312, Dec. 2024, doi: 10.11591/ijece.v14i6.pp6300-6312.

Suzanne Lenhart and John T. Workman, Optimal Control Applied to Biological Models. London: CRC Press, 2007.




DOI: https://doi.org/10.15548/jostech.v5i1.10420

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